Improved Diagnosis of Congenital Heart Disease by Magnetic Resonance Imaging Using Vasovist

• Status: Unknown status
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Magnetic Resonance Imaging (MRI) is an effective and radiation free method of diagnosing Congenital Heart Disease (CHD). MRI works by taking images of the anatomy and physiology. These images also provide information on the hearts function and blood flow. The clarity of these images is enhanced by the use of contrast agents (dyes). However these agents only stay in the blood vessels for a short time and therefore limit the time in which the better quality images can be obtained. This study aims to determine whether MRI using Vasovist (a dye that stays in the vessels for a prolonged period of time) can improve the diagnosis of Congenital Heart Disease (CHD) by allowing more areas to be imaged and the improved assessment of various parameters (anatomy, volumes, flow) as well as vastly improving image quality.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guy's Hospital

Criteria

Inclusion Criteria:

• The main inclusion criteria will be patient with CHD, i.e. complex congenital defects such as:

1. Aortic abnormalities

2. Pulmonary artery abnormalities

3. Systemic or pulmonary venous abnormalities

4. The study will be limited to patients aged 18 and over

Exclusion Criteria:

• The study will involve MR contrast agents and and MRI scans, therefore the principle exclusion criteria are:

1. Any contra-indications to MR (e.g. pacemakers)

2. Known allergy to MR contrast agents

3. Patients not agreeing to take part in study

4. Pregnancy and nursing mothers