Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin

• Status: Completed
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to show that the intake of L-arginine and metformin improves muscle function and delays disease progression in patients with Duchenne's muscular dystrophy.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Molecular diagnosis of DMD

• Patients 7 - 10 years of age at time of screening

• Ambulant

Exclusion Criteria:

• Previous (3 months or less) or concomitant participation in another therapeutic trial

• Use of L-arginine, L-citrulline or metformin within the last 3 months

• Known individual hypersensitivity to L-citrulline or metformin

• Other chronic disease or clinical relevant limitation of renal, liver, heart function according to discretion of the investigator