Improving 24-hour Blood Pressure in Obstructive Sleep Apnea

• Status: Not yet recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study examines the combined effects of an angiotensin receptor blocker (ARB), antioxidant supplementation, and continuous positive airway pressure (CPAP) therapy on the lowering of 24-hour blood pressure in persons with moderate to severe Obstructive Sleep Apnea (OSA). All participants will undergo CPAP therapy as prescribed by their doctor; however, half of the participants will receive the combined ARB and antioxidant treatment while the other half of the participants will receive a placebo.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of British Columbia
• Collaborators: Heart and Stroke Foundation of Canada; Michael Smith Foundation for Health Research
• Treatments: Angiotensin Receptor Antagonists; Antioxidants; Telmisartan; Thioctic Acid

Criteria

Inclusion Criteria:

• Apnea/Hypopnea Index (AHI) greater than/equal to 15 events per hour of sleep

• No prior use of CPAP

• Body mass index less than 30kg/m2

• Does not take ARBs or angiotensin converting enzyme inhibitors for blood pressure control

• Females of childbearing potential on an effective or highly effective means of contraception

Exclusion Criteria:

• Prescribed and/or taking the following medications: diuretics (including potassium-sparing diuretics), Digoxin, lithium salts, and/or nonsteroidal anti-inflammatory drugs

• Over the counter supplements that affect the cardiovascular system, such as fish oils, vitamins, or other antioxidants

• History of heart failure

• History of myocardial infarction

• History of coronary artery disease

• History of stroke

• History of diabetes mellitus

• History of impaired renal function

• History of chronic obstructive pulmonary disease

• History of asthma

• History of central sleep apnea

• Smoked within the past year

• Hypotensive (Systolic blood pressure (SBP) <90 mmHg and diastolic blood pressure (DBP) <60 mmHg)

• Females who do not have a means of contraception, are pregnant, planning to become pregnant, and/or are breast-feeding