Improving Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease
Status:
Completed
Trial end date:
2023-08-30
Target enrollment:
Participant gender:
Summary
Researchers have found a link between chronic obstructive pulmonary disease (COPD) and heart
disease; however, a link is all they have found. Cardiovascular health in COPD is controlled
by different mechanisms including vascular health and systemic inflammation. The
investigators have collected preliminary data to support that concentrations of Sirtuin 1
(Sirt1), a protein that plays a key role in cardioprotection, may be involved in
cardiovascular health in patients with COPD. Resveratrol, an over the counter natural
polyphenol found in a variety of food, is a direct activator of Sirt1 and has been used to
improve cardiovascular health in different cohorts. The current project is an attempt to
expand previous findings and explore the effects of the sub-chronic use of resveratrol in
sustaining the improvements in cardiovascular health in COPD.