Improving Stroke Rehabilitation: Spacing Effect and D-cycloserine
Status:
Completed
Trial end date:
2011-11-01
Target enrollment:
Participant gender:
Summary
Each year 730,000 Americans experience a stroke. Forty percent are left with significant
paralysis of one arm. Certain types of physical therapy, for example constraint induced
movement therapy (CIMT), have been shown to be effective in improving arm function. However,
for most subjects, improvement is modest. In this trial, we test two approaches that may
increase the amount of improvement achieved: 1) distributing treatment over a greater amount
of time; and 2) adding a drug, d-cycloserine, which theoretically enhances the molecular
mechanisms of learning.
Phase:
Phase 2
Details
Lead Sponsor:
US Department of Veterans Affairs VA Office of Research and Development