Impulsivity Domains and Subjective Response

• Status: Recruiting
• Trial end date: 2027-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Findings from this project will determine the relationship between two vulnerability factors for Alcohol Use Disorder (AUD) in young adults: impulsivity and subjective response to alcohol. The results will identify badly needed, novel targets for prevention and treatment efforts to simultaneously reduce impulsivity and subjective responses in at-risk young adults.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Jessica Weafer
• Collaborator: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Criteria

Inclusion Criteria:

• 21-25 years old

• Report drinking to an estimated BAC > .08% at least once in the past 30 days based on responses on the Timeline Followback (TLFB)

• Report drinking at least twice weekly in the past 30 days based on responses on the TLFB

• Fluency in English

Exclusion Criteria:

• Any serious medical problems (e.g., liver disease, cardiac abnormality, pancreatitis, diabetes, neurological problems, and gastrointestinal disorders)

• Body weight < 110 or > 210 pounds

• Axis I psychiatric disorders including substance use disorder other than mild or moderate alcohol or mild cannabis use disorder

• Current alcohol withdrawal or history of medically-assisted detoxification

• Two positive breath alcohol concentration (BrAC) readings (i.e., > 0.00%) at an in-person screening appointment or experimental session

• Positive urine screen for illegal drugs other than cannabis

• Currently seeking or past-12-month history of inpatient or intensive treatment for addictive behaviors

• Current psychotropic medication use or receipt of a prescription for these medications in the past 30 days

• Psychosis or other psychiatric disability

• Pregnancy, nursing or lack of reliable birth control use for women

• Report smoking > 5 cigarettes per day (to avoid acute nicotine effects or withdrawal during experimental sessions)