In Vitro Myometrial Contractions in Laboring and Non-laboring Women
Status:
Completed
Trial end date:
2012-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the ability of an isolated sample of uterine muscle
tissue (in a tissue bath) to contract in the presence of various drugs. The drugs
studied--uterotonics--are typically used to contract the uterus when a pregnant patient
continues to bleed after delivery. Amongst common uterotonic drugs, namely oxytocin,
ergonovine, prostaglandin F2alpha, and misoprostol, the most effective one to use is unknown.
The investigators will be testing isolated uterine muscle samples to increasing
concentrations of these four drugs in three patient populations: non-laboring, laboring
without exogenous oxytocin augmentation, and laboring with oxytocin augmentation. Contractile
measures will be measured and compared between all groups. The investigators hypothesize that
oxytocin alone will have a weaker uterotonic effect in oxytocin-augmented laboring patients,
and all four drugs will induce different patterns of contractions.
Phase:
N/A
Details
Lead Sponsor:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Collaborators:
Canadian Anesthesiologists' Society University of Toronto