In Vivo Assessment of Cellular Metabolism in Humans

• Status: Active, not recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This is a pilot study to establish an arterial venous methodology to measure the activity of the TCA cycle or flux directly in tissues of human beings. It will also perform correlative studies to study the proteome, metabolome, oxygen consumption, carbon dioxide production and exosomes derived from the arterial venous supply of tissues with correlation to the TCA cycle activity.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: K. Sreekumaran Nair
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Glucagon; Glucagon-Like Peptide 1; Hormones; Somatostatin

Criteria

INCLUSION CRITERIA:

• Ages 18-45

• Able to provide written consent

EXCLUSION CRITERIA:

• Diabetes mellitus or impaired fasting glucose levels (fasting blood glucose >110mg/dl).

• Renal Failure

• Pregnancy

• Steroid use

• Muscle Disease

• Liver Disease

• Major Depression

• Anemia

• H/O alcohol use

• Medications other than OCPs

• BMI of 30 or greater