In Vivo Quantification of Dental Demineralisation Using OCT With and Without Esomeprazole
Status:
Completed
Trial end date:
2008-05-01
Target enrollment:
Participant gender:
Summary
Dental erosions in 30 male and female patients with proven abnormal gastrooesophageal reflux
will be assessed clinically and using a novel optical coherence tomography (OCT) laser
technique before and after double-blind randomization to antisecretory treatment with
esomeprazole 20mg or placebo bid for 3 weeks.
The primary objective is to quantify tooth substance loss as well as changes in optical
reflectance and scattering of dental hard tissues with and without acid inhibition.
Secondary objectives are:
To compare standardised visual scoring with OCT quantification of reflux damage at the
different time points on different teeth.
To assess sex differences in OCT- quantified dental tissue loss.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Brain-Gut Research Group
Collaborator:
Beckman Laser Institute University of California Irvine