Increased Cefazolin During Cesarean Delivery in Obese Population
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether an increased prophylactic dose (3 grams) of
cefazolin at the time of cesarean delivery has superior coverage in adipose tissue than the
current established dosing of 2 grams. The tissue and serum concentration values, when using
an increased prophylactic dose, can then be compared to our pilot study assays in hopes of
determining an optimal dosing for the obese and morbidly obese populations undergoing
cesarean delivery.
A previous study performed at University of California, Irvine (UCI) and Long Beach Memorial
Medical Center/Miller Children's Hospital (LBMMC) showed that the standard dose of
antibiotics (2 grams of cefazolin) did not provide adequate coverage for all organisms in the
obese and extremely obese populations. The purpose of this research study is to evaluate
whether in increased dose of antibiotics given before cesarean delivery (3 grams of
cefazolin) will reach adequate levels in adipose (fat cells underneath the skin) and serum
(blood) samples. In addition, researchers hope to evaluate if/how the mother's weight has an
effect on the levels of antibiotics in the tissues (a group of similar cells).
This follow up study (prior study HS# 2009-7015 at UCI) will enroll obese (Body Mass Index
(BMI) of 30-40) and morbidly obese (BMI >40) women to receive an increased dose of
prophylactic cefazolin at time of scheduled cesarean delivery at both UCI and LBMMC.
Researchers hope to enroll a total of 35 women overall.