Independent Studies of Dextromethorphan and of Donepezil Hydrochloride for Rett Syndrome

• Status: Unknown status
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Rett syndrome (RTT) is a disorder in which the nervous system does not develop properly. RTT generally affects girls, but there are some boys who have been diagnosed with RTT. Symptoms of RTT include small brain size, poor language skills, repetitive hand movements, and seizures. This study will evaluate the effectiveness of two drugs in treating the symptoms of RTT.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• Treatments: Dextromethorphan; Donepezil

Criteria

Inclusion Criteria

• Diagnosis of Rett syndrome

• Mutation in MeCP2 gene

• Typical EEG abnormalities (disorganized background, frontal central spikes, rhythmic theta)

Exclusion Criteria

• Features of Rett syndrome with absence of MeCP2 mutation

• Non-specific EEG changes