Index of Microcirculatory Resistance After Drug-Eluting Stent Implantation With High Dose Atorvastatin Loading

• Status: Unknown status
• Trial end date: 2012-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Pre-treatment with statins decreased the incidence of cardiac enzyme increase after percutaneous coronary intervention (PCI) and distal embolization suspected to cause post-PCI myocardial damage. This study evaluates the effect of high dose atorvastatin pre-treatment on post-procedural index of microcirculatory resistance (IMR) values that are introduced for assessing the status of the microcirculation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Korean Society of Circulation
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• Patients of Non-ST elevation acute coronary syndrome planed to elective percutaneous coronary intervention

Exclusion Criteria:

• ST elevation myocardial infarction

• Cardiogenic shock

• Congestive heart failure with pulmonary edema

• Severe left ventricular dysfunction (LVEF < 30%)

• History of previous coronary revascularization therapy

• chronic total coronary occlusion

• 3 vessel disease

• Target lesion at distal segments or branches

• Ostial lesion

• Excessive coronary calcification or thrombi

• Elevated transaminase

• Renal dysfunction (serum creatinine > 2.0mg/dL

• History of myopathy

• Contra-indication to anti-platelet therapy

• Not indicated for percutaneous coronary intervention

• Other co-morbidity with life expectancy less than 1 year