Overview

Individual Dosing of Levothyroxine After Thyroidectomy

Status:
Recruiting

Trial end date:
2023-06-10

Target enrollment:
0

Participant gender:
All

Summary

Recently, Zaborek et al. raised a Poisson regression model for levothyroxine(LT4) dosing scheme to predict individual dose of LT4 after thyroidectomy: daily LT4 dose=e[2.02+0.01(W)-0.0037(A )-0.098(F)-0.01(B)+0.007(T)+0.108(I)-0.014(M), where W is the weight of the patient (Kg), A is the age of the patient (years), and F is the gender (for women 1, male is 0), B represents the patient's body mass index (BMI), T represents the preoperative TSH level, I represents whether the patient takes iron preparations (1, if not 0), M represents whether the patient takes multivitamins/minerals (1, if not 0). We demonstrated its value with our retrospective data in our center. Therefore, we intend to carry out this randomized controlled trial in order to further evaluate the model. The clinical significance of this method can provide a basis for the future use in clinical optimization of individualized dosing.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Second Affiliated Hospital, School of Medicine, Zhejiang University

Criteria

Inclusion Criteria:

- patients underwent total/near-total thyroidectomy or completion thyroidectomy;
patients with benign disease, or low-risk differentiated thyroid cancer, or medullary
thyroid cancer who don't need TSH suppressive therapy;

Exclusion Criteria:

- patients with heart disease or severe liver/kidney insufficiency; patients taking
liothyronine in addition to levothyroxine;