Individualized Cefepime Dosing Study

• Status: Completed
• Trial end date: 2016-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Several population pharmacokinetic (PK) models for cefepime in critically ill patients have been described, all indicating that variability in renal clearance is the main determinant of observed variability in exposure. The main objective of this study was hence to determine which renal marker best predicts cefepime clearance.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Onze Lieve Vrouw Hospital
• Collaborator: University Ghent
• Treatments: Cefepime; Cephalosporins

Criteria

Inclusion Criteria:

• Patient age 18 years or more

• Hospitalized in the ICU of OLV hospital Aalst

• Elected by the treating physician to receive cefepime,irrespectively of the study

• Presence of arterial or central line for blood sampling

Exclusion Criteria:

• Exact time of cefepime administration or blood sampling unknown

• No written informed consent by the patient or his/her (legal) representative