Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO

• Status: Not yet recruiting
• Trial end date: 2025-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.

An individualized transfusion strategy based on ScVO2 level, is compared to a conventionnal strategy based on predefined hemoglobin threshold. The primary endpoint is the consumption of packed red blod cells, secondary endpoints are subgroup analysis, mortality, morbidity, and cost-effectiveness

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Lille
• Collaborators: Amiens University Hospital; Centre hospitalier de Dunkerque; Centre Hospitalier de Lens; Centre Hospitalier Universitaire Dijon; University Hospital, Caen; University Hospital, Rouen

Criteria

Inclusion Criteria:

• Age of 18 and older,

• supported by peripheral VA-ECMO

• for cardiogenic shock

• Life expentency >90 days

• Central venous line available ScVO2 measurement

Exclusion Criteria:

• Pregnancy,

• Lack of health insurance,

• Opposition to blood transfusion,

• Known congenital hemoglobin disease or disorder,

• Metabolic alcaloosis with pH>7.8,

• eCPR,

• Legally incapacitated adults