Individualizing Dose of Growth Hormone to Maintain Normal Growth Velocity After Fulfilled Catch up Growth in Children

• Status: Completed
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective was to study whether normal growth velocity can be maintained with adapted GH dosage in GH treated prepubertal children who have responded to GH treatment with fulfilled catch up growth (=difference to target height reached, less than - 0.6 SDS).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Göteborg University
• Collaborator: Pfizer
• Treatments: Hormones

Criteria

Inclusion Criteria:

• Participated in the 'GH-dose catch-up study' 98- 0198-003.

• Midparental height reached (difference less than 0.6 SDS)

• Prepubertal at start of the study (girls =B 1, boys: testes :<; 3ml).

• Signed written informed consent from the patient's parents (and the child if old enough)

Exclusion Criteria:

• Disease affecting growth other than correctly treated hypothyroidism.

• Incapable of following the study protocol (i.e. bad compliance in the previous study).

• Puberty (> breast stage 2, or testes > 4ml).

• Poor compliance.