Indo-cyanine Green (ICG) in Paediatric Oncology MIS

• Status: Recruiting
• Trial end date: 2022-09-30
• Target enrollment: 0
• Participant gender: All

Summary

Indo-cyanine green (ICG) is a dye that has been used for a variety of adult and paediatric uses since 1956. Over the past few years, near infrared (NIRF) technology has been developed which allow is use as a fluorescence agent during surgery. It has been used increasingly in the field of adult oncology surgery and has been shown to increase the efficacy of this surgery.

The aim of this study is to evaluate the use of NIRF and ICG during specific minimally invasive surgery (MIS) procedures within paediatric oncology surgery. Their use will complement existing surgical techniques rather than replace them.

Given the published advantages in adults this study aims to provide evidence of feasibility in the paediatric patients with cancer.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Birmingham Women's and Children's NHS Foundation Trust

Criteria

Inclusion Criteria:

• Age between 1 day and 15 years 365 days

• Have a diagnosis of an intra-abdominal, retroperitoneal or intra-thoracic tumour or pulmonary metastases

• Require surgery as part of their treatment

• Tumour or metastasis suitable for MIS resection based on assessment of the pre-operative imaging

Exclusion Criteria:

• Allergic to ICG

• Allergic to iodine or iodides

• Due to receive radioactive iodine as part of a treatment

• Hyperthyroidism

• Unwilling to participate

• Chronic Kidney Disease stage V