Indomethacin and Cardiac Bypass Surgery

• Status: Completed
• Trial end date: 2002-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Following signed informed consent, patients scheduled for elective cardiac surgery were randomly assigned to one of 3 groups to be given acetaminophen, Indomethacin or a combination of both immediately following induction and then at 6, 12, 18 & 24 hours following surgery. Our primary outcome measure was the amount of blood drained from the mediastinal tubes and chest drains. Secondary outcome measures included conventional blood coagulation indices as well as other measures of clotting as indicated by thromboelastography (TEG). Other secondary outcome measures included consumption of morphine equivalents and pain scores.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Queen's University
• Treatments: Acetaminophen; Indomethacin; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

• scheduled to undergo either elective coronary artery bypass or single valve replacement

• normal platelet count

• normal prothrombin time

• normal partial thromboplastin time

• normal serum creatinine

Exclusion Criteria:

• sensitivity to study drugs

• history of bleeding diathesis

• renal dysfunction

• active peptic ulcer