Induced Adult Refractory Active Crohn's Disease Clinical Relieving by Using Thalidomide
Status:
Unknown status
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
With the development and application of biological agents, the treatment effect was
considerable degree improvement on refractory corn's disease. However, there are quite a part
of the CD patients lost response during treatment of using response. Moreover, due to various
reasons, there still a lot limited on the using of biological agents in China, that make
quite a part of the refractory CD patients lack of further medical treatment options. There
has been a RCT study which prove that thalidomide effect and safety on treating refractory CD
or who were lost response by using biological agents in Italy, but the object of study is
only limited in children and adolescents. There are some small sample studies also confirmed
the efficacy and safety on refractory corn's disease by using thalidomide, but need more RCT
evidence.