Induction Chemotherapy, Chemoradiotherapy and Surgery in Locally Advanced Gastric Cancer Patients

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to evaluate the efficacy of a neoadjuvant approach in patients with locally advanced gastric cancer and the identification of prognostic factors.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Clinica Universidad de Navarra, Universidad de Navarra

Criteria

Inclusion Criteria:

• Histologically confirmed adenocarcinoma of the stomach

• Age ≥18 years old

• Performance Status- Eastern Cooperative Oncology Group (ECOG) 0-1

• Body mass index ≥ 18

• No prior chemotherapy or chemoradiotherapy

• TNM stage of T3-T4 and/or positive regional lymph nodes (N+) by endoscopic ultrasound or computed tomography (CT)

• No evidence of metastasis (M0)

• Adequate hematological, liver and renal functions (ALT and AST≤2.5 UNL, total bilirubin ≤1.5 UNL, and serum creatinine ≤1.5 UNL)

Exclusion Criteria:

• Patients with previous (less than 10 years) or current history of malignant neoplasms, except for curatively treated

• Patients with evidence of severe or uncontrolled systemic disease

• Medically unfit for chemotherapy

• Tumors involving the esophageal junction, comprising siewert I to III