Induction Chemotherapy Followed by Standard Therapy in Cervical Cancer With Aortic Lymph Node Spread
Status:
Recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
The main objective of this study is to determine whether neoadjuvant chemotherapy with
Carboplatin and paclitaxel plus standard cisplatin-based chemoradiation with extended fields
improves overall survival rates compared to standard therapy alone in women with cervical
cancer with paraaortic lymph node involvement.
Women in the experimental arm will receive neoadjuvant chemotherapy with carboplatin and
paclitaxel every 21 days during 3 cycles followed by standard therapy with extended field
external radiation therapy and concomitant chemotherapy. Women in the control arm will
receive standard therapy with extended field external radiation therapy and concomitant
chemotherapy.
310 patients will be recruited during 3 years, with 3 years of follow up period.