Induction Chemotherapy,Radiochemotherapy, Consolidation Chemotherapy in Preoperative Treatment of Rectal Cancer
Status:
Unknown status
Trial end date:
2018-04-01
Target enrollment:
Participant gender:
Summary
The use of capecitabine based preoperative chemoradiation and adjuvant chemotherapy is
standard treatment of locally advanced rectal cancer. It has reduced local recurrence rate to
less than 10%, but has only had limited effect on overall survival due to the constantly high
(more than 30%) rate of distant metastasis.
Complete eradication of the primary tumour observed in the histopathological specimen
(pathological complete response, pCR) correlates with a favourable overall prognosis so
obtaining a pCR might be beneficial. The aim of the study is to investigate whether the
addition of capecitabine based chemotherapy before preoperative chemoradiation and also
before the operation improves pathological complete remission rate in locally advanced rectal
cancer with acceptable toxicity. Secondary objectives are to evaluate pathological
downstaging rate, histopathological R0 resection rate,sphincter preservation rate,
perioperative surgical complication rate, local control, DFS, OS, late toxicity and quality
of life.