Overview

Induction Chemotherapy and Immunotherapy Combined Radiotherapy With or Without Concurrent Chemotherapy for Stage III-IVa NPC

Status:
Not yet recruiting
Trial end date:
2028-01-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to compare induction chemotherapy (gemcitabine+cisplatin) plus immunotherapy with concurrent chemoradiotherapy (CCRT) or RT alone in patients with stage III-IVa nasopharyngeal carcinoma(NPC), in order to confirm the value of Immunotherapy and concurrent chemotherapy in NPC patients.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Fujian Cancer Hospital
Treatments:
Cisplatin
Criteria
Inclusion Criteria:

- Patients with newly histologically confirmed non-keratinizing (according to WHO
histologically type).

- Tumor staged as III-Iva(except T3N0M0) (according to the 8th AJCC edition).

- No evidence of distant metastasis (M0).

- Satisfactory performance status: Karnofsky scale (KPS) ≥ 70.

- Adequate marrow: leucocyte count ≥ 4000/μL, hemoglobin ≥ 90g/L and platelet count ≥
100000/μL.

- Normal liver function test: Alanine Aminotransferase (ALT), Aspartate Aminotransferase
(AST) < 1.5×upper limit of normal (ULN) concomitant with alkaline phosphatase (ALP) ≤
2.5×ULN, and bilirubin ≤ ULN.

- Adequate renal function: creatinine clearance ≥ 60 ml/min.

- Patients must be informed of the investigational nature of this study and give written
informed consent.

Exclusion Criteria:

- WHO Type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma.

- Age > 65 or < 18.

- Treatment with palliative intent.

- Prior malignancy except adequately treated basal cell or squamous cell skin cancer, in
situ cervical cancer.

- Pregnancy or lactation (consider pregnancy test in women of child-bearing age and
emphasize effective contraception during the treatment period).

- History of previous RT (except for non-melanomatous skin cancers outside intended RT
treatment volume).

- Prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes.

- Any severe intercurrent disease, which may bring unacceptable risk or affect the
compliance of the trial, for example, unstable cardiac disease requiring treatment,
renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose >
1.5×ULN), and emotional disturbance.