Induction and Expansion of T Cell Repertoire Using Growth Hormone and Vaccination in HIV-1 Infected Patients
Status:
Completed
Trial end date:
2009-07-01
Target enrollment:
Participant gender:
Summary
Concomitant administration of recombinant human growth hormone (rhGH) may boost the expansion
of immune reconstitution and broaden specific T cell responses not achievable by vaccination
alone. The main objective of that study is to test the validity of this hypothesis with
vaccines which are routinely administered to HIV-1 patients(tetanus toxoid and hepatitis A
virus vaccines) in order to, if proven of value, use this strategy of HIV vaccination in the
near future. This is a pilot, randomized, clinical open label study aimed to investigate
thymic functionality and the HIV-specific responses after administration of rhGH in HIV-1
infected patients in highly active antiretroviral therapy (HAART) regimen.
Phase:
Phase 4
Details
Lead Sponsor:
Germans Trias i Pujol Hospital
Collaborators:
Carlos III Health Institute Hospital Clinic of Barcelona Hospital General Universitario Gregorio Marañon