Induction of Anesthesia With Sevoflurane Preserving Spontaneous Breathing: Cardiorespiratory Effects.

• Status: Completed
• Trial end date: 2021-07-14
• Target enrollment: 0
• Participant gender: All

Summary

Airway management is of outmost importance in the perioperative period. One of the main questions while making a plan for airway management is whether spontaneous ventilation should be maintained or not. Induction of anesthesia with Sevoflurane is a conventional technique that preserves spontaneous ventilation. It is used especially in non-collaborating patients or when other pharmaceutical agents or sophisticated airway management equipment is out of reach.

Inhalational induction of anesthesia with Sevoflurane is well studied. However, there are few studies investigating the effects of Sevoflurane on induction and intubating conditions, on cardiopulmonary physiology, on emergence conditions, when it is used as one and only agent to achieve induction of anesthesia, intubation and maintenance of anesthesia in adult patients. There is also no consensus on the appropriate duration of the inhalational induction or other criteria to guarantee successful intubation conditions, since most studies investigate Sevoflurane administration until induction of anesthesia and not until intubation.

From all the above, it appears that there are a few gaps in the management of patients who are to be intubated with Sevoflurane only, without the use of any other anesthetic agents.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aristotle University Of Thessaloniki
• Treatments: Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Age >18 and < 71 years

• ASA-PS 1-3 (American Society of Anesthesiologists Physical Status classification)

• General anesthesia for abdominal surgery

• Elective cases

• Signed informed consent

Exclusion Criteria:

• Urgent/emergency surgeries

• BMI<18.5 or BMI>34.9

• Intraabdominal hypertension

• Gastroesophageal reflex

• Pregnancy

• Liver or renal failure

• intracranial hypertension