Induction of Labor by Oral Misoprostol Solution

• Status: Completed
• Trial end date: 2018-11-30
• Target enrollment: 0
• Participant gender: Female

Summary

AIM: To evaluate effectiveness and safety of titrated oral misoprostol solution (OMS) in comparison with static-dose oral misoprostol solution for induction of labor at term.

Women with singleton live pregnancy at term without any complications who were admitted in labor room for induction of labor were enrolled.

Study involves allocation of selected women in two groups randomly and use of either titrated or static oral misoprostol dose regimen to induce labor. Possible benefits included rapid induction of labor with oral drug regimen which is easier to comply as compared to vaginal regimens. Women were at risk of all the complications associated with induction of labor like labor abnormalities, risk of cesarean section, non reassuring fetal status.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Christian Medical College and Hospital, Ludhiana, India
• Treatments: Misoprostol

Criteria

Inclusion Criteria:

1. Singleton live pregnancy;

2. ≥37 weeks gestation;

3. Cephalic presentation;

4. Reassuring fetal heart rate;

5. Modified Bishop'score

Exclusion Criteria:

1. Hypersensitivity to misoprostol;

2. Uterine scar due to previous cesarean section or other uterine surgery;

3. Grand multipara;

4. Multiple gestations;

5. High risk pregnanacies • preeeclampsia with severe features • significant maternal cardiac,renal, liver disease

6. Any contraindication to induction and vaginal delivery e.g. cephalopelvic disproportion, malpresentation, fetal compromise and ante partum hemorrhage

7. Intrauterine fetal demise