Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis

• Status: Terminated
• Trial end date: 2017-05-23
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: M.D. Anderson Cancer Center
• Treatments: Doxycycline; Fentanyl

Criteria

Inclusion Criteria:

1. Outpatients with MPE undergoing IPC placement

2. Age 18 or older

3. Sufficient mental capacity to answer SF-6D and Borg score questions.

Exclusion Criteria:

1. Patients undergoing pleurodesis for benign disease (e.g., spontaneous pneumothorax)

2. Inability or unwillingness to give informed consent

3. Inability to perform phone call and clinical follow-up at MDACC

4. Previous intrapleural therapy for MPE on the same side

5. Chylous effusions associated with malignant disease

6. ECOG of 4 and life expectancy

7. Doxycycline allergy

8. Contraindication to placement of an IPC (e.g., uncorrected coagulopathy)