Osteoarthritis (OA) is the most common cause of disability in older adults worldwide
affecting 7% of the global population, or more than 500 million people globally. Total joint
replacements (TJR) can help bring relief to those with osteoarthritis when other treatment
options are no longer helpful. Infection is the main reason hip and knee replacements "fail".
Failure leads to repeat surgeries that are often more complicated and less likely to be
successful than the first surgery. Reducing the risk of infection is extremely important,
antiseptic washes and antibiotics may help us do that. After joint replacement surgery,
orthopaedic surgeons wash and clean the surgical wound to lower the risk of infection. The
goal of this clinical trial is to determine if the use of antiseptic solutions to wash the
surgical site and placing an antibiotic directly into the wound will reduce the number of
infections requiring reoperation. Patients having total joint replacements will be randomized
(like flipping a coin) to receive 6 possible combinations of washes and / or antibiotics.
Participants will be followed for one year after TJR to compare the rate of infection in each
group.
Phase:
Phase 3
Details
Lead Sponsor:
Hamilton Health Sciences Corporation
Collaborators:
McMaster University Ontario Clinical Oncology Group (OCOG)