Inflammation and Vascular Function in Atherosclerosis

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether reducing inflammation in blood vessels with an aspirin-like drug called salsalate will improve blood vessel function.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Salicylsalicylic acid; Sodium Salicylate

Criteria

Inclusion Criteria:

• Non-smoking adult subjects with known atherosclerosis

Exclusion Criteria:

• Uncontrolled hypertension (> 140/90 mmHg)

• Untreated hypercholesterolemia (LDL > 160 mg/dL)

• Diabetes mellitus

• Alanine Aminotransferase > 150

• Creatinine > 1.4 mg/dL

• Concommitant use of warfarin