Inflammatory Axis and Sirtuins' in Overweight Pre-diabetics Patients

• Status: Completed
• Trial end date: 2018-01-01
• Target enrollment: 60
• Participant gender: All

Summary

In obese patients the superficial adipose tissue works as an endocrine active tissue to express different cytokines, and multiple molecular pathways implied in the cross talking with different part of the human body, such as the cardiovascular system. To date, adipocytes and adipose tissue-derived macrophages and adipose tissue synthesize, and secrete several cytokines, and sirtuins. In this setting, the excess of body fat is linked to heart contractile dysfunction. All these pathways are differently expressed in obese diabetic patients as compared to obese non diabetic patients. Intriguingly, in diabetic obese patients the hyper-expression of inflammatory cytokines is associated to a hypo-expression of sirtuins. Therefore, this molecular pattern in diabetic obese patients may correlate to altered myocardial performance, and to the development of heart failure disease. In this study authors will evaluate at baseline by peripheral blood samples and by the abdominal fat tissue, the expression of cytokines and sirtuins comparing pre-diabetics obese patients vs. non pre-diabetics obese patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Campania "Luigi Vanvitelli"
• Treatments: Metformin

Criteria

Inclusion Criteria:

• body mass index > 30;

• prediabetes;

• normal glycemic blood profile;

• both gender;

• age > 18 and < 65 years old.

Exclusion Criteria:

• body mass index < 30;

• diabetes;

• age < 18, and > 65 years old.