Influence of Aging on Perioperative Methadone Dosing

• Status: Recruiting
• Trial end date: 2021-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Increasingly, elderly patients undergo anesthesia and surgery. Methadone is a great opioid for perioperative pain management, however, to date there are no pharmacokinetic or pharmacodynamic studies that asses a methadone dose adjustment in the elderly patient. The present study is aimed to characterize the pharmacokinetic and pharmacodynamic age-related changes of methadone in the adult population and further to design reference dosing protocols for intraoperative methadone use according to patient age.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pontificia Universidad Catolica de Chile
• Treatments: Methadone

Criteria

Inclusion Criteria:

1. Over 18 years.

2. ASA I, II or III.

3. Laparoscopic Abdominal Surgery.

Exclusion Criteria:

1. BMI> 35

2. Use of opioids up to 5 days before surgery.

3. Acute Liver Failure or Chronic Liver Damage Child C.

4. Kidney damage with creatinine clearance estimated by Cockcroft-Gault formula <60 ml/min.