Influence of Aging on Perioperative Methadone Dosing
Status:
Recruiting
Trial end date:
2021-09-01
Target enrollment:
Participant gender:
Summary
Increasingly, elderly patients undergo anesthesia and surgery. Methadone is a great opioid
for perioperative pain management, however, to date there are no pharmacokinetic or
pharmacodynamic studies that asses a methadone dose adjustment in the elderly patient. The
present study is aimed to characterize the pharmacokinetic and pharmacodynamic age-related
changes of methadone in the adult population and further to design reference dosing protocols
for intraoperative methadone use according to patient age.