Influence of Albumin on Acute Renal Dysfunction Associated With Cardiac Surgery Under Extracorporeal Circulation
Status:
Unknown status
Trial end date:
2019-08-01
Target enrollment:
Participant gender:
Summary
Acute renal dysfunction associated with cardiac surgery (DRA-ACC) in our hospital population
affects 39% of patients, being an important cause of morbidity and mortality, increasing the
need for dialysis and assuming a prolongation of stay in the unit of intensive care, as well
as an increase in the economic cost.
In this sense, extracorporeal circulation (CPB) is a clear aggression for renal function due
to multiple effects, not entirely known.
Human albumin is sometimes used as part of the priming of the CEC circuit in variable
concentration according to published centers and studies, demonstrating benefits on the
maintenance of plasma oncotic pressure during the period of ECC, as well as other effects
that can protect renal function during this period of renal injury.
Despite the use of albumin in the ECC priming both in Spain and in other countries, there are
currently no published studies demonstrating the effect of albumin on renal function
administered during CPB in cardiac surgery during the postoperative period. with a high
incidence of kidney injury, although there are current studies that confirm a decrease in the
incidence of kidney injury in patients with hypoalbuminemia and who undergo heart surgery
without extracorporeal circulation.
The hypothesis of this study is based on the potential protective effect of albumin on renal
function in patients undergoing heart surgery under CPB, in which there is a high incidence
of postoperative hypoalbuminemia.
This study aims to obtain information about the effect that albumin can have in this
population of patients with a high incidence of acute renal dysfunction, and if this benefit
exists, whether it is significant or not to justify its systematic use.
Phase:
Phase 4
Details
Lead Sponsor:
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau