Influence of Anesthetic Drugs on Extubation After General Anesthesia

• Status: Recruiting
• Trial end date: 2024-03-31
• Target enrollment: 0
• Participant gender: All

Summary

Recovery period of general anesthesia refers to the period from the end of anesthesia infusion to recovery of the patient after the operation. In patients with general anesthesia, the depth of anesthesia is reduced in the early stage of recovery, the cerebral cortex is still in a state of inhibition, and the subcortical center is often in a state of high sensitivity to external stimulation. At this time, due to drug effects, pain, hypoxemia, undetected aspiration, pneumothorax, urinary retention, tracheal catheter stimulation, urinary tube stimulation and other factors, the patient will be induced to appear restless reaction, and cause drastic changes in hemodynamics. Especially for the elderly with organ dysfunction, it may increase postoperative complications, prolong hospital stay and increase hospital costs.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lili Jia
• Treatments: Dexmedetomidine; Nalbuphine

Criteria

Inclusion Criteria:

• (1) Age ≥55, gender unlimited;

(2) ventilator assisted ventilation after endotracheal intubation;

(3) General anesthesia surgery;

Exclusion Criteria:

• (1) Allergy to the drugs used in this study;

(2) any sedative, analgesic, antiemetic or antipruritic drugs taken 24 hours before the operation;

(3) History of severe bradycardia (heart rate < 50 beats/min);

(4) moderate to severe hepatic and renal dysfunction;

(5) Patients with neurological diseases;