Influence of Antiviral Treatment to the Long-Term Prognosis of Patients With Chronic HBV Infection

• Status: Unknown status
• Trial end date: 2017-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Influence of antiviral treatment to the long term prognosis of patients with chronic HBV infection. The aim of antiviral treatment for HBV is to reduce the long term severe complications. In this study, the investigators divided patients with chronic HBV infection into two groups, which start early antiviral treatment and conventional antiviral treatment respectively. All the patients will be followed for ten years. From this study, the investigators want to find out the optimal time for patients with chronic HBV infection to start antiviral treatment.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sun Yat-sen University
• Treatments: Adefovir; Adefovir dipivoxil; Antiviral Agents; Lamivudine; Telbivudine

Criteria

Inclusion Criteria:

• HBsAg positive for more than 6 months.

• HBeAg positive.

• HBV DNA over 10E5 copies/ml.

Exclusion Criteria:

• Previous antiviral treatment for HBV.

• Co infection of HIV, HCV, HEV, HAV, or HAV.

• Evidence of hepatic carcinoma.

• Evidence of autoimmune disease.

• Evidence of thyroid disease.

• History of mental sickness.