Influence of Atorvastatin on Psoriasis Severity and Endothelial Function
Status:
Withdrawn
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
Patients with psoriasis seem to have increased risk for developing atherosclerosis. This may
be due to the fact that psoriasis and atherosclerosis are both caused by inflammation and
involvement of cells of the immune system. Atherosclerosis is frequently treated by statins
(class of cholesterol lowering drugs), which lower bad cholesterol levels and also reduce
inflammation. Some new evidences also suggest that therapy with statins may improve psoriasis
skin disease.
The current study aims are to evaluate whether a strong statin named Atorvastatin can improve
psoriatic skin disease and functioning of the arteries. The study also aims to evaluate if
the activity of these two diseases are related to levels of common inflammatory biomarkers
(substance in blood) and whether Atorvastatin can change their levels.