Influence of CBD on Episodic Memory in Healthy Subjects

• Status: Completed
• Trial end date: 2018-12-08
• Target enrollment: 0
• Participant gender: All

Summary

Placebo controlled, randomized, double blind, cross-over design.

Single vape of 0.25ml 5% CBD e-liquid (12.5mg CBD) and single vape of 0.25ml e-liquid, tastes like lemon and madeleine. 15min vape time each.

A total of 34 participants, equal number of male and female. There will be replacement of Drop-Outs until data from 34 participants are completed.

The primary endpoint will be performance in a verbal memory task. The secondary endpoint will be performance in a working memory test.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Prof. Dominique de Quervain, MD

Criteria

Inclusion Criteria:

• Healthy

• Normotensive (BP between 90/60mmHg and 140/90mmHg)

• BMI between 18 and 30 kg/m2

• Male or female

• Aged between 18 and 30 years

• Native or fluent German-speaking

• Able and willing to give written informed consent as documented by signature and comply with the requirements of the study protocol

• Willing to donate urine sample to control for pre-Visit CBD/THC consume

Exclusion Criteria:

• Acute or chronic psychiatric disorder including drug or alcohol abuse

• Women who are pregnant or breast feeding

• Intention to become pregnant during the course of the study

• Smoking (> 5 cigarettes per day)

• Participation in one of our previous studies using the same verbal test in the past 2 years

• Participation in a study with CBD / THC within the 30 days preceding and during the present study

• Known hypersensitivity or allergy to propylene glycol

• Intake of CBD / THC within the 7 days preceding and during the present study in any application form

• Long-term systemic medication or topical steroids to treat an underlying disease within last 3 months

• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant

• Enrolment of the investigator, his/her family members, employees and other dependent persons