Influence of CYP3A4-induction by St. John's Wort on the Steady State Pharmacokinetics of Bosentan
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
The aim of the present study is to assess the impact of the cytochrome P450 2C9 (CYP2C9)
genotype (*2 and *3 allele versus wild type; ~3-5% poor metabolisers in Caucasian population)
on the pharmacokinetics of bosentan and the impact of CYP3A4-induction by St. John's wort
(SJW) on steady state bosentan which is a CYP3A4 inducer itself.