Influence of Caloric Restriction and Resveratrol in the Sirtuin System in Women and Men Aged 55 to 65 Years
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Women have a natural protection that gives them greater longevity. One hypothesis most
commonly used is the estrogen protection in the premenopausal period. However many studies of
various forms of hormone replacement therapy proved ineffective in promoting additional
protection for women. Thus, it is discussed other ways of protection associated with
longevity in women. Of these, the sirtuin system was found in several animal studies to be
associated with longevity. This system also showed, through the involvement of several
metabolic pathways, an important protection against the process of atherosclerosis. But the
activity of this system in humans is unknown and if it is more active in women than in men.
The study's main objectives are to analyze this system in healthy 24 women and 24 men aged 55
to 65 years, and their influence on the main metabolic pathways related to longevity and the
process of atherosclerosis. The research protocol includes analysis of the influence of
sirtuin (SIRT1) in vascular reactivity, lipid profile, antioxidant capacity, markers of
inflammation and homeostasis, before and after the interventions with caloric restriction or
resveratrol administration. It is expected of this study mechanistic conclusion for longevity
and possible clinical applications in the mechanism of atherosclerosis prevention.