Influence of Cytochrome CYP3A4-induction by St. John's Wort on the Steady State Pharmacokinetics of Ambrisentan
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
The aim of the present study is to assess the impact of CYP3A4-induction by SJW on steady
state ambrisentan and the impact of the cytochrome P450 2C19 (CYP2C19) genotype (*2 and *3
allele vs. wild type; ~2-5% poor metabolisers in Caucasian population) on the
pharmacokinetics of ambrisentan in healthy volunteers.