Influence of Dexmedetomidine or Propofol on ICU Delirium

• Status: Recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

In this randomized study, the investigators aim to test the hypothesis that the reinstitution of a normal circadian rhythm by continuous infusions of dexmedetomidine compared to propofol between 8pm and 6am after diagnosis of hyperactive or mixed delirium, decreases the duration of delirium. The infusions might have to be repeated several times to achieve resolution of delirium.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• Adult patients (age 18 years or older) in a state of delirium (hyperactive ore mixed type) upon detection in the ICU (i.e., ICDSC >3).

Exclusion Criteria:

• Hypersensitivity to the active substance

• Advanced heart block (grade 2 or 3) unless implanted pacemaker

• Uncontrolled hypotension

• Severe cardiac dysfunction

• Bradycardia

• Egg allergy

• Soybean/soy allergy

• Age below 18 years

• Terminal state

• Pregnancy

• Active psychosis (of non organic origin = functional disturbances)

• Status epilepticus or postictal states following seizures on EEG