Influence of Dopaminergic Blockade on Stress Responses, Motivation and Emotional Reactivity in Humans.

• Status: Completed
• Trial end date: 2020-07-15
• Target enrollment: 0
• Participant gender: All

Summary

The study aims to identify whether partial blockade of human dopamine signaling with antipsychotic drugs affects human stress responses, motivation and emotion. 84 healthy adult participants are planned to complete the study protocol.

Therefore three experiments are planned:

Experiment 1: Influence of amisulpride on human stress responses. Experiment 2: Influence of amisulpride on motivated effort. Experiment 3: Influence of amisulpride on emotion.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Philipps University Marburg Medical Center
• Collaborators: University of Hamburg; University of Hamburg-Eppendorf
• Treatments: Amisulpride; Dopamine; Dopamine Agonists

Criteria

Inclusion Criteria:

• Common European Framework of Reference for Languages level B2 in German language.

• Consent ability for all relevant aspects of the experiment.

Exclusion Criteria:

• Amisulpride allergy.

• Allergy to other components of amisulpride / placebo capsules like lactose.

• Daily intake of other medication including contraceptives.

• Tendency to seizures.

• Diagnosis of cancer especially pheochromocytoma, prolactinoma, or breast cancer.

• Kidney dysfunction: creatinine clearance below 10 ml per minute.

• High risk for stroke or thrombosis.

• Known prolongation of the QT interval,

• Any substantial medical condition that is capable of reducing the volunteers ability to participate at the study.

• Suicidal thoughts or suicide attempts in the past or at present.

• Substantial mental disorders especially schizophrenia, bipolar disorder, drug abuse, or personality disorders.

• Pregnancy or breastfeeding.