Overview

Influence of Gut Hormones on Food Intake After Roux-en-Y Gastric Bypass Surgery

Status:
Completed

Trial end date:
2016-06-01

Target enrollment:
0

Participant gender:
All

Summary

The aim of this study is to examine the effect of GLP-1 and other gut-secreted hormones (glucagon, GIP, grelin and PYY) on food-intake, appetite and glucose metabolism after Roux-en-Y gastric bypass surgery.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Hvidovre University Hospital

Collaborator:

University of Copenhagen

Treatments:

Hormones
Sitagliptin Phosphate

Criteria

Inclusion Criteria:

- Uncomplicated RYGB performed 3-12 month proir to the study. Fasting plasma glucose
<7.0 mM and HbA1c < 48 mmol/mol 3 month after RYGB.

Exclusion Criteria:

- Fasting plasma glucose >7.0 mM and HbA1c > 48 mmol/mol 3 month after RYGB. Hemoglobin
<6.5mM. Previous anaphylaxis when treated with Januvia or Byetta. Allergy for
sitagliptin. Dysregulated hypothyroidism. Use of antithyroid treatment. Late diabetic
complications as retinopathy, renal insuffiency, neuropathy or previous pancreatitis.
Bad compliance.

- Complications to RYGB: Documented reactive hypoglycaemia, severe dumping (with
vomiting, diarrhea or severe abdominal pain after food intake).