Influence of Intraoperative Analgesia on the Postoperative Morphine Consumption
Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
Unlike longer acting opiates (sufentanil), remifentanil may provoke postoperative
hyperalgesia. We have developed two automated bispectral index - guided drug delivery
systems: one for propofol administration, the other for combined propofol and remifentanil
administration. Both systems achieve the same objective: similar level of anesthesia
indicated by bispectral index levels between 40 to 60. We make the assumption that this
method of automated remifentanil administration may avoid postoperative hyperalgesia.
Patients scheduled for abdominal surgery will be divided into two groups:
- in one group, patients will receive automatically delivered propofol and manually
delivered sufentanil according to the usual criteria,
- in the other group, patients will receive propofol and remifentanil both automatically
administered.
Assessment of postoperative hyperalgesia will be primarily based on morphine consumption
(patient controlled analgesia) and detection of cutaneous hyperalgesia areas.