Influence of Mechanical Ventilation Modes on the Efficacy of Nebulized Bronchodilator
Status:
Unknown status
Trial end date:
2019-12-10
Target enrollment:
Participant gender:
Summary
Aerosol therapy is widely used in intensive care in critically ill patients that use
mechanical ventilation (MV). However, there is a lack of standardization about aerosol
performance in this group of patients. Thus, this study aims to evaluate the effect of
nebulization performed in different ventilatory modes on lung function and regional pulmonary
distribution of critical patients with chronic obstructive pulmonary disease. It is a
clinical trial, crossover, randomized, controlled and blind. Three interventions with
bronchodilators will be performed: in the Pressure Controlled Ventilation mode (PCV) with
positive end expiratory pressure (PEEP) = 85% of autoPEEP, in the PCV mode with PEEP = 15
cmH2Oand in the Pressure Support Mode (PSV). Pulmonary function data will be evaluated
through Electrical Impedance Tomography to evaluate the efficacy of the bronchodilator in
different ventilatory modes.