Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer

• Status: Completed
• Trial end date: 2009-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effect of high-dose n-acetylcysteine on inflammatory reaction, pulmonary morbidity, oxygenation and quality of life in patients undergoing transthoracic, partial or total resection of the esophagus for cancer.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Collaborator: Triemli Hospital
• Treatments: Acetylcysteine; Anesthetics; N-monoacetylcystine

Criteria

Inclusion Criteria:

• elective, abdomino-thoracic esophagectomy

• elective, thoraco-abdomino-cervical esophagectomy

• age 20-90 years

• informed consent given

Exclusion Criteria:

• emergency procedures

• patients with increased bronchorrhoea

• hypersensitivity against n-acetylcysteine

• pregnancy

• lactation