Influence of Neostigmine vs. Sugammadex on PORC and PPCs by Ultrasonography

• Status: Not yet recruiting
• Trial end date: 2022-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This trial aims to compare the incidence of postoperative residual curarisation (PORC) and postoperative pulmonary complications (PPCs) in the SUG and NEO group by means of diaphragm ultrasonography and LUS, so as to conclude whether SUG can outperform NEO in preventing occurrence of PORC and PPCs.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking Union Medical College Hospital

Criteria

Inclusion Criteria:

1. American Society of Anesthesiologists (ASA) physical status I-III

2. Aged over 60 years

3. Anesthesia induction with rocuronium as NMBAs, maintenance with volatile sevoflurane

4. Scheduled to undertake joint surgery

5. Signed the informed consent form

Exclusion Criteria:

1. Those with a history of hepatic or renal disease, chronic or acute alcoholism, allergy or hypersensitivity to sugammadex or neostigmine, current medication with effects on the central nervous system, a history of dysfunction of neuromuscular system

2. Those with diaphragm insufficiency or massive pleural effusion

3. Women who are pregnant or nursing

4. Those undergoing upper abdominal laparotomy, after which we cannot obtain a satisfactory ultrasound imaging or do not have space for placement of ultrasonic probe

5. Declined to participate