Influence of Oral Vitamin C Supplement on the Inflammation Status in Dialysis Patients
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
Subclinical inflammation is a common phenomenon in patients receiving maintenance
hemodialysis (MHD). This is because various pro-inflammatory cytokines are promoted due to
metabolic acidosis, volume overload, and / or non-sterile dialysate.
As important antioxidants, vitamin C was prominently consumed by oxidative stress and
inflammation. So patients receiving dialysis therapy usually had a low plasma vitamin C
level.
It was documented that inflammation was associated with increased risk of cardiovascular
morbidity and mortality in patients on dialysis. But the relationship between plasma Vitamin
C and each of inflammatory markers and prealbumin was lacking. Because vitamin C had
anti-inflammation effect on behalf of its electron receiving ability, the investigators made
a hypothesis that vitamin C supplementation can reduce inflammation status in patients on
maintenance dialysis