Influence of Oral Vitamin C Supplement on the Inflammation Status in Dialysis Patients

• Status: Completed
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Subclinical inflammation is a common phenomenon in patients receiving maintenance hemodialysis (MHD). This is because various pro-inflammatory cytokines are promoted due to metabolic acidosis, volume overload, and / or non-sterile dialysate.

As important antioxidants, vitamin C was prominently consumed by oxidative stress and inflammation. So patients receiving dialysis therapy usually had a low plasma vitamin C level.

It was documented that inflammation was associated with increased risk of cardiovascular morbidity and mortality in patients on dialysis. But the relationship between plasma Vitamin C and each of inflammatory markers and prealbumin was lacking. Because vitamin C had anti-inflammation effect on behalf of its electron receiving ability, the investigators made a hypothesis that vitamin C supplementation can reduce inflammation status in patients on maintenance dialysis

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Peking University First Hospital
• Treatments: Ascorbic Acid; Vitamins

Criteria

Inclusion Criteria:

• Patients receiving maintenance hemodialysis or continuous ambulatory peritoneal dialysis, and dialysis vintage more than 3 months

• Patients aged between 18 and 80 years older

• VitC < 4ug/ml and hsCRP > 3mg/L

• for HD patients, Kt/V > 1.2 per session, at least 3 sessions per week, 4 hours per session

• for PD patients, Kt/V > 1.7 per week

• age and gender matched health control

Exclusion Criteria:

• Active autoimmune disease, malignancy, hepatitis

• Positive HIV serology

• Any kind of acute infection within one month, chronic infection

• Currently using steroids or immune-suppressants

• Pregnancy or breast feeding