Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene

• Status: Completed
• Trial end date: 2014-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

Aim of the study is the clinical validation of the metabolism and the pharmakokinetic of Clomifen in correlation to CYP2D6 and inhibition of CYP3A4.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Robert Bosch Gesellschaft für Medizinische Forschung mbH
• Treatments: Clarithromycin; Clomiphene; Enclomiphene; Paroxetine; Zuclomiphene

Criteria

Inclusion Criteria:

• Healthy

• Female caucasians

• Age 18 - 45 years old

• BMI 18.5 - 26 kg/m2

Exclusion Criteria:

• Persons with known sensitivity of Clomifen and/or Paroxetine and/or Clarithromycin

• Pregnancy/lactation period

• Meno-/postmenopausal

• Smokers