Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

• Status: Completed
• Trial end date: 2017-05-12
• Target enrollment: 0
• Participant gender: All

Summary

Purpose

1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test.

2. To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital Inselspital, Berne
• Treatments: Fludrocortisone; Furosemide

Criteria

Inclusion Criteria:

• One or more episodes of nephrolithiasis

Exclusion Criteria:

• Absence of informed consent

• All conditions affecting renal acidification

• Pregnancy

• Nursing