Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Brief summary: In order to get a better clinical plan for brain protection during perioperative anesthesia for high-risk patients - carotid intima stripped. We observing the hemodynamic changes of sevoflurane post-treatment in carotid intima stripped, the comparison of postoperative cognitive function and postoperative radiographic changes.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Treatments: Sevoflurane

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists（ASA）：II-III

• Aged between 40 and 80 years

• Patients scheduled for surgery of Carotid stenosis under general anaesthesia

Exclusion Criteria:

• Has a history of mental illness can't cooperate,

• Serious heart block or cardiac decompensation or severe sinus slow (HR < 50 times/min),

• The abnormal nerve monitoring in operation, MMES preoperative score < 20 points,

• Any rescue unexpected occurred during the operation